Dr. Ravi Thadhani, M.D., M.P.H.

Vice Dean, Research and Education, Cedars-Sinai

Dr. Ravi Thadhani, M.D., M.P.H. is Vice Dean, Research and Education at Cedars-Sinai. He received his Doctor of Medicine degree from the University of Pennsylvania in 1991, and in 1997 received his Masters in Public Health in Epidemiology from the Harvard School of Public Health.

He is a clinical and translational investigator and over the past 16 years his research laboratory has focused on understanding vitamin D metabolism and on developing diagnostics and therapeutics related to preeclampsia. In dialysis, he has examined the effect of vitamin D in the survival of chronic hemodialysis patients. These series of observational studies have included thousands of dialysis patients throughout the U.S. His studies have been confirmed by over 25 independent investigators world-wide. Clinical practices (academic and non-academic) have implemented practice patterns aligned with this work, and national and international practice guidelines have highlighted these studies. Acknowledging the observational nature of this work, however, he pursued animal models examining the cardiac effects of vitamin D with basic science collaborators. His series of human and animal experimental studies led to an investigator initiated (Thadhani, PI) multicenter multinational (> 60 centers world-wide) clinical trial in patients with kidney disease (e.g., PRIMO – Paricalcitol benefits in Renal Insufficiency associated cardiac Morbidity, clinicaltrials.gov NCT00497146). PRIMO is the first randomized trial in nephrology to test the hypothesis that active vitamin D therapy favorably affects cardiac hypertrophy and diastolic dysfunction. His team coordinated the entire study and the top-line results were published in JAMA in 2012. Several additional national and international studies including follow-up studies in the general population (e.g., VITAL) are ongoing. Concerning preeclampsia, Dr. Thadhani and his collaborators have developed novel diagnostic tests, and are now arduously working on therapies to safely prolong pregnancy in women with very severe preterm preeclampsia. He has several grants, invited speaking events, book chapters, and publications in these areas, including invited commentaries.

Dr. Thadhani has significant experience in research training and has formally supervised and trained 25 post-doctoral fellows, many of whom now occupy faculty research positions at Harvard Medical School and other institutions throughout the world and who have secured their own funding from the National Institutes of Health, the American Society of Nephrology, American Heart Association, Juvenile Diabetes Association, and the National Kidney Foundation among other sources. He serves as mentor and advisory committee member of several renal fellows, as well as several post-doctoral fellows. He established his interdisciplinary clinical research laboratory at Massachusetts General Hospital in 1999 and it consists of fellows, junior and senior faculty members, a data manager, statisticians, laboratory technicians, nurses, research study coordinators/assistants, and students (http://thadhanilab.org/). The theme of his laboratory has been on translational research and he has a strong track record of collaborating with basic scientists. The lab conducts observational studies, basic science research, and clinical trials with the goal of finding new diagnostic approaches and therapeutic interventions for patients with kidney disease and related disorders.

He has served as a reviewer for and has published in several journals including New Engl J Med, the Lancet, J Am Soc Nephrol, Kidney Int, and J Clin Endocrinol Metab. A complete list of his published work may be found at the following link: http://www.ncbi.nlm.nih.gov/sites/myncbi/ravi.thadhani.1/bibliograpahy/43478162/public/?sort=date&direction=ascending

Dr. Thadhani has been the recipient of numerous honors and awards including the 2008 American Society of Clinical Investigation, Inducted Member; the 2014 Alumni Award of Merit from the Harvard School of Public Health Alumni Association; the 2015 American Association of Physicians, Inducted Member; and the 2015 Robert W. Schrier Endowed Lectureship from The American Society of Nephrology. In January 2016, Dr. Thadhani was the recipient of Honors for Outstanding Contributions in Nephrology Research & Education from the International Society of Nephrology & American Nephrologists of Indian Origin. His current support includes 7 grants from the NIH as well as private corporations. He is a member of the American Society of Nephrology, American Society of Clinical Investigation, National Kidney Foundation, and the Association of American Physicians. Finally, Dr. Thadhani is a sought-after lecturer and presenter at regional, national, and international venues on topics such as Translational Studies in CKD, Preeclampsia, and Vitamin D.

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